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Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(2022-10-20)
Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to
demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D
printing process ...
Role of CD73 in patients with advanced melanoma treated with anti-PD-1 agents
(2022-04-22)
The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of
immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD-
1), such as nivolumab and pembrolizumab. ...
Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(2022-05-02)
The aim of this Ph.D. project is the development of novel topical formulations for the treatment of
various wounds by innovative technologies (micro and nano spray drying). The specific objective is
the production of a dry ...
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(2022-04-27)
There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to
characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ...
High-throughput virtual screening by molecular dynamics assisted molecular docking.
(2022-04-29)
Molecular docking is a widely used Structure-Based method for drug discovery. Over the years,
molecular docking methodologies have evolved to address several limitations, such as high errors in
predicting pose and binding ...
Design and synthesis of small molecules as ion channel modulators
(2022-05-02)
My PhD research plan relates the exploration of the structural requirements for ionic channels
modulation such as TRPM8 and Kv7 receptors.
About the first field, we prepared a series of tryptophan-based derivatives of our ...
Role of H3K56 acetylation in Candida albicans virulence
(2022-12-20)
Candida spp., especially Candida albicans, represent the third most frequent cause of infection in
Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal
resistance drastically ...
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(2022-04-26)
Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono
la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile
che include il peptide di ...
Development of Innovative Agents for the Treatment of Metabolic Diseases
(2022-05-10)
Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the
leading cause of death in the world. To date three main therapeutic strategies have been evaluated to
reduce circulating LDL-C ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...