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Role of CD73 in patients with advanced melanoma treated with anti-PD-1 agents
(2022-04-22)
The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of
immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD-
1), such as nivolumab and pembrolizumab. ...
Molecular basis of cardiomiopathy
(2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Role of TFF1 in tumor progression
(2017-03-31)
Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(2017-03-28)
Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...