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Development of novel anticancer compounds directed towards promising therapeutic targets
(2023-04-19)
Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role
in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant
activity in proteins involved in this crucial ...
Targeted and untargeted proteomic approaches to disclose small molecules interactome
(2023-04-24)
The identification of natural products and synthetic compounds target proteins is pivotal to
understand their mechanism of action for the development of molecular probes and/or potential drugs.
Functional proteomics is a ...
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(2020-10-24)
The identification of natural products (NPs) target proteins is pivotal to understand their
mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years,
affinity chromatography-coupled ...
Design, synthesis and biological activity of new target selective antitumoral agents
(2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
Design and synthesis of molecules with anti-inflammatory and/or anti-cancer activit
(2022)
Nell'ultimo decennio, il legame tra infiammazione e cancro è risultato sempre più evidente; di conseguenza, l'identificazione di nuove molecole in grado di interferire con i targets biologici chiave coinvolti in queste ...