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Development of novel anticancer compounds directed towards promising therapeutic targets
(2023-04-19)
Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role
in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant
activity in proteins involved in this crucial ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...