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Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(2022-04-26)
Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono
la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile
che include il peptide di ...
Bioactives from agricultural food by-products: application in food and health
(2017-04-04)
Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ...
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(2022-10-20)
Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to
demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D
printing process ...
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(2017-03-31)
Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert
beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties
of bioactive extracts ...
Role of CD73 in patients with advanced melanoma treated with anti-PD-1 agents
(2022-04-22)
The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of
immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD-
1), such as nivolumab and pembrolizumab. ...
Development of novel anticancer compounds directed towards promising therapeutic targets
(2023-04-19)
Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role
in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant
activity in proteins involved in this crucial ...
Analytical procedures for the safety assessment of dietary supplements and botanicals
(2023-04-06)
The consumption of dietary supplements and botanicals is not always safe and free of potential
health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a
group of plant secondary ...
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(2023-04-13)
My PhD research plan relates to the exploration of the structural requirements for the modulation
of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part
of my doctoral project ...
Role of H3K56 acetylation in Candida albicans virulence
(2022-12-20)
Candida spp., especially Candida albicans, represent the third most frequent cause of infection in
Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal
resistance drastically ...