Sfoglia Translational Medicine @ UniSa per Titolo
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The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors
(2016)Mast cell and basophils express the high affinity receptor for IgE (FcRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological ... -
Three Dimensional Myocardial Deformation and Diagnosis of Stable Coronary Artery Disease
(2015)To date, only one third of patients, with stable angina, undergoing coronary angiography demonstrated obstructive coronary artery disease (CAD). Thus, identifying high sensitivity and specificity, low-cost, non invasive ... -
To be or not to be translational
(2013)Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the ... -
To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
(2012)Nuclear factor B (NFB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFB is constitutively expressed in tumours where it induces ... -
Tracheostomy in spinal cord injured patients
(2011)Patients with cervical spinal cord injury frequently need prolonged mechanical ventilation as a result of worsening pulmonary vital capacity due to paralysis of respiratory muscles, severe impairment of tracheobronchial ... -
Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization
(2014)G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently ... -
Transcatheter implantable devices to monitoring of elevated left atrial pressures in patients with chronic heart failure
(2017)Elevated left atrial (LA) pressures are associated with poor prognosis in heart failure (HF). Invasive monitoring of LA-pressures and direct mechanical LAdecompression are associated with functional improvement in ... -
Transculturality: the new frontier of care relationships
(2012)Taking care of migrants constitutes a new challenge for the actual operative structures of the services in general and for the sanitary service in particular, requiring a global and permanent rethinking with regards ... -
Treatment of clavicle fractures
(2012)Clavicle fractures are very common injuries in adults (2-5%) and children (10-15%) (1) and represent the 44-66% of all shoulder fractures (2). Despite the high frequency the choice of proper treatment is still a challenge ... -
Treatment of de novo femoro-popliteal lesions with a new Drug Coated Balloon: early experience of a single Center in the first 50 patients
(2018)Angioplasty with drug-coated balloon (DCB) is an emerging and reliable method for the treatment of femoro-popliteal lesions. We report our experience with the Stellarex™ DCB in the first 50 patients. Methods - From ... -
Unique association of rare cardiovascular disease in an athlete with ventricular arrhythmias
(2015)Ventricular arrhythmias are a leading cause of non-elegibility to competitive sport. The failure to detect a significant organic substrate in the initial stage of screening does not preclude the identification of structural ... -
Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
(2016)The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPIanchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. uPAR also regulates cell adhesion, migration and ... -
Use of equine pericardium sheet (lyomesh®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery
(2013)Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary ... -
The use of noninvasive ventilation outside the intensive care unit: a clinical case report
(2013)Noninvasive Ventilation (NIV) is one of the best weapon at our disposal to treat respiratory failure. The early use of NIV out of the Intensive Care Unit can improve patients’ outcome. A 58-year-old man affected ... -
Use of the directional atherectomy for the treatment of femoro-popliteal lesions in patients with critical lower limb ischemia
(2016)Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant ... -
The Validity of Adding ECG to the Preparticipation Screening of Athletes. An Evidence Based Literature Review
(2015)Objective: To review the available evidence establishing the validity of adding electrocardiogram to the preparticipation cardiac screening in athletes. Data Sources: MEDLINE and CINAHL databases were searched. Additional ... -
Vaptans and hyponatremia in critical patients
(2012)Hyponatremia is the most frequent fluid and electrolyte disorder in hospitalized patients (20%), particularly in ICU, associated with an increase in morbility and mortality. While hypovolaemic hyponatremia needs to be ... -
Ventricular septal defect: the three-dimensional point of view
(2013)This case highlights the clinical usefulness of three-dimensional (3D) echocardiography. The diagnosis of inter-ventricular septal defect associated with aortic regurgitation has been performed in a 50-year-old man using ...