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The clinical significance of delirium in the intensive care unit
(2012)
Delirium is prevalent among intensive care unit patients. It prolongs length of stay, increases costs, and is independently associated with higher mortality rates. While its specific biological pathways are largely unknown, ...
Posttranscriptional gene regulation: novel pathways for glucocorticoids? Anti-inflammatory action
(2012)
Posttranscriptional gene regulation
(PTR) is a fundamental biological process that
integrates with the master transcriptional control of
gene expression, in ways that only in the last decade
have been increasingly ...
Angiogenesis in Chronic Obstructive Pulmonary Disease: A Translational Appraisal
(2012)
Angiogenesis is a crucial component
of lung pathophysiology, not only in cancer but
also in other disorders, such as chronic
obstructive pulmonary disease (COPD). In
COPD angiogenesis is definitely able to control
and ...
Sisters acts: converging signaling between CaMKII and CaMKIV, two members of the same family
(2012)
Calcium (Ca2+
) is a universal second
messenger that regulates a number of diverse cellular
processes including cell proliferation, development,
motility, secretion, learning and memory1, 2. A variety of
stimuli, ...
Pediatric health mobility: is it only an italian problem?
(2012)
Intra-regional, extra-regional and
international health mobility are important
phenomena for regional and national healthcare
planning. Pediatric data on this topic are scarce. We
therefore conducted a systematic ...
Minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs
(2012)
Purpose: To develop a clinically relevant
porcine model for the study of hepatic metabolism of drugs
by means of hepatic vein catheterization.
Materials and Methods: review of literature and
elaboration of a hypothesis, ...
Breakthrough pain: the importance of baseline analgesic regimen with opioids
(2012)
Pain is one of the most common and often most
feared symptoms in patients with cancer. Ongoing or
progressive pain is physically debilitating and has a
marked impact on quality of life. During their illness, at
least ...
Sepsis-associated encephalopathy
(2012)
Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct brain infection. Its ...
To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
(2012)
Nuclear factor B (NFB) is a transcription
factor that plays an important role in carcinogenesis as well
as in the regulation of inflammatory response. NFB is
constitutively expressed in tumours where it induces ...