Translational Medicine @ UniSa: Recent submissions
Now showing items 201-220 of 284
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Management of Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention
(2014)Atrial fibrillation (AF) is the most common cardiac arrhythmia, occurring in 1-2% of overall population, involving more than 6 millions of European people. It is associated to a reduced quality of life and an increased ... -
A Low Cost Amplifier And Acquisition System For Cortical-Electroncephalography In Non-Human Applications
(2014)A simple circuit is described to make an AC-amplifier and an analog-to-digital converter in a single, compact solution, for use in basic research, but not on humans. The circuit sends data to and is powered from a common ... -
Genomics DNA Profiling in Elite Professional Soccer Players: A Pilot Study
(2014)Functional variants in exonic regions have been associated with development of cardiovascular disease, diabetes and cancer. Athletic performance can be considered a multi-factorial complex phenotype. Genomic DNA was extracted ... -
Redesigning Service Delivery for Hypertensive Patients: A Methodological Guideline to Improve the Management of Chronic Diseases
(2014)Best care is not necessarily the most expensive, but the most appropriate, and prevention is the most powerful tool to promote health. A novel approach might envision the reduction of hospital admittance (thus meeting a ... -
Immunologic Changes in Frail Older Adults
(2014)Several studies have shown a heightened inflammatory state in frail older adults, marked by high serum levels of interleukin-6 and C-reactive protein and an increased number of circulating leukocytes. Activation of monocytes ... -
Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
(2014)Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular ... -
Are T-LGL leukemia and NK-chronic lymphoproliferative disorder really two distinct diseases?
(2014)Mature Large Granular lymphocytes (LGL) disorders include a spectrum of conditions, ranging from polyclonal to clonal indolent and/or overt leukemic LGL proliferations. Most cases are represented by clonal expansions of ... -
Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics
(2014)Clonal non-malignant hematological disorders are a heterogeneous group of diseases that are particularly challenging for hematologists. Indeed, most obvious and frequent hematological diseases include a broad spectrum of ... -
Errata corrige
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Monoclonal B-cell lymphocytosis
(2014)Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, ... -
Current Concepts on Diagnosis and Treatment of Mastocytosis
(2014)Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease ... -
Molecular Genetics of Myelofibrosis and its associated Disease Phenotypes
(2014)In 2005, the discovery of Janus kinase 2 (JAK2) V617F mutation in approximately half of patients with myelofibrosis (MF) marked an important milestone in our understanding of the pathophysiology of MF. This has broadened ... -
Anti-complement treatment in paroxysmal nocturnal hemoglobinuria: where we stand and where we are going
(2014)Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, non-malignant, hematological disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ... -
Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ... -
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ... -
Use of equine pericardium sheet (lyomesh®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery
(2013)Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary ... -
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ...
