Mostra i principali dati dell'item

dcterms.contributor.authorGiudice, Valentina
dcterms.contributor.authorRicci, Pier Carlo
dcterms.contributor.authorMarino, Luigi
dcterms.contributor.authorRocco, Mattia
dcterms.contributor.authorVillani, Gaetano
dcterms.contributor.authorLangella, Monica
dcterms.contributor.authorManente, Lisa
dcterms.contributor.authorSeneca, Elisa
dcterms.contributor.authorFerrara, Idalucia
dcterms.contributor.authorPezzullo, Luca
dcterms.contributor.authorSerio, Bianca
dcterms.contributor.authorSelleri, Carmine
dc.date.accessioned2020-05-22T12:51:05Z
dc.date.available2020-05-22T12:51:05Z
dcterms.date.issued2016
dcterms.identifier.citationGiudice V, Ricci P, Marino L, Rocco M, Villani G, Langella M, Manente L, Seneca E, Ferrara I, Pezzullo L, Serio B, Selleri C. In vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cells. Translational Medicine @ UniSa 2016, 15(4): 22-33.it_IT
dcterms.identifier.issn2239-9747it_IT
dcterms.identifier.urihttp://www.translationalmedicine.unisa.it/indexit_IT
dcterms.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/4480
dcterms.identifier.urihttp://dx.doi.org/10.14273/unisa-2678
dc.description.abstractFarnesyltransferase inhibitors (FTIs) are a class of oral anti-cancer drugs currently tested in phase I-II clinical trials for treatment of hematological malignancies. The in vitro effects of various FTIs (alpha-hydroxyfarnesylphosphonic acid, manumycin-A and SCH66336) were tested on CD34+ KG1a cell line and in primary acute myeloid leukemia (AML) cells from 64 patients. By cell viability and clonogeneic methylcellulose assays, FTIs showed a significant inhibitory activity in CD34+ KG1a and primary bone marrow (BM) leukemic cells from 56% of AML patients. FTIs also induced activation of caspase-3 and Fas-independent apoptosis, confirmed by the finding that inhibition of caspase-8 was not associated with the rescue of FTItreated cells. We concluded that other cellular events induced by FTIs may trigger activation of caspase-3 and subsequent apoptosis, but the expression of proapoptotic molecules, as Bcl-2 and Bcl-XL, and antiapoptotic, as Bcl-X(s), were not modified by FTIs. By contrast, expression of inducible nitric oxide synthase (iNOS) was increased in FTI-treated AML cells. Our results suggest a very complex mechanism of action of FTIs that require more studies for a better clinical use of the drugs alone or in combination in the treatment of hematological malignancies.it_IT
dcterms.format.extentP. 22-33it_IT
dc.language.isoenit_IT
dcterms.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dcterms.subjectAcute myeloid leukemiait_IT
dcterms.subjectFarnesyltransferase inhibitorsit_IT
dcterms.subjectApoptosisit_IT
dcterms.subjectNitric oxideit_IT
dcterms.titleIn vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cellsit_IT
dcterms.typeArticleit_IT
 Find Full text

Files in questo item

FilesDimensioneFormatoMostra

Nessun files in questo item.

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item