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dc.contributor.authorMontuori, Nunzia
dc.contributor.authorPesapane, Ada
dc.contributor.authorGiudice, Valentina
dc.contributor.authorSerio, Bianca
dc.contributor.authorRossi, Francesca Wanda
dc.contributor.authorDe Paulis, Amato
dc.contributor.authorSelleri, Carmine
dc.date.accessioned2020-05-22T13:02:44Z
dc.date.available2020-05-22T13:02:44Z
dc.date.issued2016
dc.identifier.citationMontuori N, Pesapane A, Giudice V, Serio B, Rossi FW, De Paulis A, Selleri C. 67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach? Translational Medicine @ UniSa 2016, 15(2): 8-14.it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://www.translationalmedicine.unisa.it/indexit_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/4482
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2680
dc.description.abstractThe 67 kDa laminin receptor (67LR) is a non-integrin cell surface receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced invasive and metastatic potentialin many human solid tumors, recommending this receptor as a new promising target for cancer therapy. This is supported by in vivo studies showing that 67LR downregulation reduces tumour cell proliferation and tumour formation by inducing apoptosis. 67LR association with the anti-apoptotic protein PED/PEA-15 activates a signal transduction pathway, leading to cell proliferation and resistance to apoptosis. However, the main function of 67LR is to enhance tumor cell adhesion to the LM of basement membranes and cell migration, two crucial events in the metastasis cascade.Thus, inhibition of 67LR binding to LM has been proved to be a feasible approach to block metastatic cancer cell spread. Despite accumulating evidences on 67LR overexpression in hematologic malignancies, 67LR role in these diseases has not been clearly defined. Here, we review 67LR expression and function in normal and malignant hematopoietic cells, 67LR role and prognostic impact in hematological malignancies and first attempts in targeting its activity.it_IT
dc.format.extentP. 8-14it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectAmininreceptorit_IT
dc.subjectLamininit_IT
dc.subjectHematopoietic stem cellsit_IT
dc.subjectLeukemiait_IT
dc.subjectMultiple myelomait_IT
dc.title67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?it_IT
dc.typeArticleit_IT
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