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Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)
The research project "Chemical and biological study of natural substances active on
the Central Nervous System" has been focused on the possible effects of essential oils,
their main constituents (in particular monoterpenes), ...
Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing
(Universita degli studi di Salerno, 2019-04-12)
The PhD project titled “Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing” aimed to develop novel formulations for topical ...
Structural investigation of gp36-MPER in membrane mimicking systems
(Universita degli studi di Salerno, 2019-05-07)
FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ...
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)
Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ...
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)
The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ...
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)
Biofluids are typical complex matrices representing a source of potential biomarkers,
but often require high demands in sample preparation prior to analysis. With this purpose,
several techniques have been developed ...
Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
(Universita degli studi di Salerno, 2021-06-17)
My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ...
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)
Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ...
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)
Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...