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Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)
The adenosinergic pathway plays a critical role in cancer development and progression, as well as
in drug resistance to chemotherapy and/or targeted-therapy.
The goal of this PhD thesis was to investigate and fully ...
Target-based study to identify new bioactive diterpenes
(Universita degli studi di Salerno, 2019-04-16)
Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ...
Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)
The research project "Chemical and biological study of natural substances active on
the Central Nervous System" has been focused on the possible effects of essential oils,
their main constituents (in particular monoterpenes), ...
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)
The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ...
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)
Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)
Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ...
Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing
(Universita degli studi di Salerno, 2019-04-12)
The PhD project titled “Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing” aimed to develop novel formulations for topical ...
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(Universita degli studi di Salerno, 2019-06-18)
In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ...
Technologies for the development of health products based on up-cycling of agro-food by-products
(Universita degli studi di Salerno, 2019-04-12)
The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ...
Functional Characterization of Candida albicans Hst3p histone deacetylase
(Universita degli studi di Salerno, 2019-05-07)
The unicellular eukaryotic organism Candida albicans is one of the most important fungi in medicine, used as experimental model to study fungal pathologies and the underlying biology of dimorphic fungi. This fungus is a ...