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dc.contributor.authorCataldi, Mauro
dc.contributor.authorBruno, Fiorentina
dc.date.accessioned2013-05-28T15:46:00Z
dc.date.available2013-05-28T15:46:00Z
dc.date.issued2012
dc.identifier.citationCataldi M, Bruno F. 1,4-Dihydropyridines: the multiple personalities of a blockbuster drug family. Translational Medicine@UniSa 2012;4(2):12-26en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/632
dc.description.abstractMore than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated Ca2+ channels, DHPs differ in crucial pharmacological properties like tissue selectivity and cardiodepressant activity. This review examines how changes in the DHP structure can modify the pharmacological properties of these drugs and how some of these chemical manipulations have been exploited to obtain clinically more effective molecules. Special emphasis is given to the evidence that L-type Ca2+ channels are an heterogeneous family and that DHPs with different pharmacological properties differ in their affinity for the different isoforms of this class of channels. Data showing that DHP pharmacological heterogeneity could be in part dependent on the interaction of some of these molecules with ion channels different from the L-type Ca2+ channels is reviewed as well.en_US
dc.format.extentP. 12-26en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectDihydropyridinesen_US
dc.subjectVoltage-gated Ca2+ channelsen_US
dc.subjectEnantiomersen_US
dc.subjectL-type channelsen_US
dc.subjectT-type channelsen_US
dc.title1,4-Dihydropyridines: the multiple personalities of a blockbuster drug familyen_US
dc.typeArticleen_US
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