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Hairy root culture as source of novel plant-derived active compounds with applications in cosmetics
(2015-04-22)
Hyperpigmentation is the process by which an excess of melanin is produced by the skin. Typically, hyperpigmentation occurs as a result of stress, damage or prolonged inflammation of the skin. The most common cause is sun ...
Role of Annexin A1 in tumor progression
(2016-10-06)
Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ...
Nuove prospettive terapeutiche del glioma: N6-isopenteniladenosina ed SR141716
(2016-03-04)
Glioma is a fatal disease characterized by uncontrolled cellular proliferation and it is
the most common primary brain malignancy in adults. Despite years of research,
malignant glioma remains one of the most aggressive ...
Nuove strategie per l'identificazione di molecole ad attività antifungina
(2013-01-30)
Con l’incremento del numero di persone affette da sindrome da immunodeficienza acquisita (AIDS), dell’uso di terapie immunosoppressive e del numero di pazienti affetti da varie forme di cancro e, dunque, fortemente debilitati ...
L'influenza del rame sull'espressione e l'attività del fattore gastrointestinaleTFF1
(2015-04-23)
Il tratto gastrointestinale rappresenta una interfaccia tra il corpo e l’ambiente esterno. È dotato di sofisticati meccanismi che ne regolano la funzionalità e attua efficaci strategie per la sua protezione affidandosi a ...
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(2016-05-10)
My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(2015-04-22)
Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it
may be a consequence of a reduced availability of this hormone, of an impediment to its normal
action, or of a combination of ...
Regolazione post-trascrizionale dell’espressione del recettore dell’urochinasi
(2016-12-14)
The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored
cell surface receptor. uPAR expression is strongly up-regulated and represents a
negative prognostic factor in various tumors, including ...
Studio del ruolo della proteina anti-apoptotica BAG3 nel melanoma umano
(2016-07-07)
BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating ...
Compression and indexing of genomic data with confidentiality protection
(2015-04-30)
The problem of data compression having specific security properties in order to guarantee
user’s privacy is a living matter. On the other hand, high-throughput systems in genomics
(e.g. the so-called Next Generation ...