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dc.contributor.authorCascone, Sara
dc.contributor.authorLamberti, Gaetano
dc.contributor.authorTitomanlio, Giuseppe
dc.contributor.authorPiazza, Ornella
dc.date.accessioned2013-11-21T12:55:33Z
dc.date.available2013-11-21T12:55:33Z
dc.date.issued2013
dc.identifier.citationCascone S, Lamberti G, Titomanlio G, Piazza O. Pharmacokinetics of remifentanil: a three-compartmental modeling approach. Translational Medicine @ UniSa 2013;7(4):18-22en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/865
dc.description.abstractRemifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics properties make remifentanil a very interesting molecule in the field of anesthesia. However a complete and versatile pharmacokinetic description of remifentanil still lacks. In this work a three-compartmental model has been developed to describe the pharmacokinetics of remifentanil both in the case in which it is administered by intravenous constant-rate infusion and by bolus injection. The model curves have been compared with experimental data published in scientific papers and the model parameters have been optimized to describe both ways of administration. The ad hoc model is adaptable and potentially useful for predictive purposes.en_US
dc.format.extentP. 18-22en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectRemifentanilen_US
dc.subjectPharmacokineticsen_US
dc.subjectThree-compartmental modelen_US
dc.titlePharmacokinetics of remifentanil: a three-compartmental modeling approachen_US
dc.typeArticleen_US
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