Sfoglia Area Scienze mediche per Data di Pubblicazione
Items 21-40 di 149
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Nuove strategie per l'identificazione di molecole ad attività antifungina
(Universita degli studi di Salerno, 2013-01-30)Con l’incremento del numero di persone affette da sindrome da immunodeficienza acquisita (AIDS), dell’uso di terapie immunosoppressive e del numero di pazienti affetti da varie forme di cancro e, dunque, fortemente debilitati ... -
BAG3 role in cardiomyocytes physiopathology
(Universita degli studi di Salerno, 2013-01-31)The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful ... -
Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti
(Universita degli studi di Salerno, 2013-02-06)Nell’ambito del progetto di ricerca dal titolo “Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti” è stato ... -
Le complicanze cardiovascolari nel diabete mellito: studio delle basi molecolari
(Universita degli studi di Salerno, 2013-02-13)Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. The assumption underlying current clinical treatment is that lowering the level of ... -
Sequence analysis in bioinformatics: methodological and practical aspects
(Universita degli studi di Salerno, 2013-04-02)My PhD research activities has focused on the development of new computational methods for biological sequence analyses. To overcome an intrinsic problem to protein sequence analysis, whose aim was to infer homologies ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
p53 regulates Mevalonate Metabolic pathway
(Universita degli studi di Salerno, 2014-03-14)The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced ... -
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ... -
The transcription factor Prep1 regulates adipose tissue functions
(Universita degli studi di Salerno, 2014-03-21)Adipose tissue is crucial for maintaining energy and metabolic homeostasis and its functionality is closely related to the adipocytes differentiation state. Adipogenesis is regulated by several transcription factors. Prep1 ... -
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ... -
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters. The title of the thesis clearly reflects the ... -
Effetti a lungo termine dell’applicazione di ammendante compostato sulla qualità chimica e biologica di suoli agrari
(Universita degli studi di Salerno, 2014-10-02)Il compost è un fertilizzante ottenuto dalla decomposizione biologica di rifiuti organici in condizioni controllate. Il processo di decomposizione biologica porta ad una parziale mineralizzazione dei composti organici più ... -
Design and synthesis of peptides that modulate apoptotic process.
(Universita degli studi di Salerno, 2014-11-17)Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ... -
Design and development of new polymeric materials with potential antimicrobial and/or antifungal activity
(Universita degli studi di Salerno, 2014-12-15)This PhD project is focused on the development of new polymeric materials with antibacterial and antifungal activity. The first part of the work was dedicated to the synthesis and the insertion of a modified amino acid ... -
Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents.
(Universita degli studi di Salerno, 2015-03-10)L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ... -
Studio dell’espressione di geni coinvolti in pathways metabolici regolati da nutrienti
(Universita degli studi di Salerno, 2015-03-10)Il profilo sierico, con particolare riferimento ai livelli di biomarkers, rappresenta uno strumento efficace ed affidabile per la diagnosi di malattie metaboliche, come il diabete o le malattie cardiovascolari. La ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ... -
Degradazione di idrocarburi policiclici aromatici (IPA) in suoli contaminati
(Universita degli studi di Salerno, 2015-03-12)Gli idrocarburi policiclici aromatici (IPA) sono composti complessi derivanti principalmente dal processo di combustione incompleta di qualunque materiale organico in carenza di ossigeno. L’interesse scientifico per questa ... -
Analysis and evaluation of potential nutracentical milk and dairy products derived from the Centrale del latte di Salerno
(Universita degli studi di Salerno, 2015-03-16)The main objective of my PhD has been focused to the analysis and characterization of milk and dairy products derived from “Centrale del Latte di Salerno” in order to assess their potential use as dietary supplements and ... -
Effetti degli acidi grassi polinsanturi sui processi di sviluppo e progressione tumorale
(Universita degli studi di Salerno, 2015-03-16)Molteplici analisi in vitro e in vivo hanno evidenziato la capacità di diversi fattori nutrizionali di influenzare i processi di carcinogenesi e di progressione tumorale. Gli acidi grassi polinsaturi (PUFA) della serie ...