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Trafficking from the Endoplasmic Reticulum to the Golgi complex and gene expression profiling during the cell stress
(Universita degli studi di Salerno, 2012-02-01)
The elucidation of the molecular mechanisms regulating the export from the Endoplasmic Reticulum (ER) and the transport to post-ER compartments of secretory proteins represents the basic aim of the present PhD project.
To ...
Il sistema adenosinico: principali targets molecolari ad attività anti-tumorale
(Universita degli studi di Salerno, 2012-02-27)
L’Adenosina (Ado) è una molecola segnale di origine purinica che esplica le sue funzioni
metaboliche mediante quattro recettori metabotropici (A1, A2A, A2B, A3). L’Ado è un
autacoide ad attività pleiotropica, che regola ...
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(Universita degli studi di Salerno, 2012-03-21)
Mapping of the interaction between STAT1 and flavonoids
Abstract
An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ...
Studio del ruolo funzionale e caratterizzazione strutturale del cuprocomplesso TFF1-Cu
(Universita degli studi di Salerno, 2012-01-26)
The maintenance of gastrointestinal tissue integrity is physiologically essential in the presence of the persistent harassment of microbial flora and injurious agents. Even though the repair of the gastric epithelium may ...
Biophysical investigation of biomolecules in bio-membrane models
(Universita degli studi di Salerno, 2012-05-30)
Many drugs are available for the treatment of systemic or superficial mycoses,
but only a limited number of them are effective antifungal drugs, devoid of
toxic and undesirable side effects. Therefore there remains an ...
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(Universita degli studi di Salerno, 2012-03-07)
The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ...
Ruolo della proteina BAG3 nel microambiente tumorale
(Universita degli studi di Salerno, 2012-02-27)
Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro. L'ambiente ipossico del tumore stimola ...
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
(Universita degli studi di Salerno, 2012-02-23)
It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ...
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)
Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization.
The study ...