Area Scienze mediche
Collezioni in questa sotto-comunità
Immissioni Recenti
-
Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare. Paramount is the necessity of re-organizing the healthcare services ... -
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ... -
Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development of a versatile screening platform for the identification of small-molecule ligands for reader proteins of the post-translational methylation
(Universita degli studi di Salerno, 2021-06-25)Covalent Post Translational Modifications (PTMs) of histone proteins are introduced and removed by the ‘writer’ and ‘eraser’ enzymes, respectively. These modifications are recognized by highly specific binding domains, ... -
Clinical characterization, genetic screening and genotype-phenotype associations in cerebellar and brainstem congenital defects
(Universita degli studi di Salerno, 2020-10-01)Cerebellar and brainstem congenital defects (CBCDs) represent a wide spectrum of malformative disorders resulting from abnormal development of midbrain-hindbrain and characterised by high clinical and genetic heterogeneity. ... -
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatogra ... -
Development of a bioengineered three-dimensional scaffold able to commit stem cells toward tenogenic phenotype
(Universita degli studi di Salerno, 2021-06-23)The term tendinopathy is a generic descriptor of tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis, with impaired biological and mechanical properties. Adult tendons have ... -
Parodontite e carcinoma del colon-retto: la possibile associazione genetica e patogenetica
(Universita degli studi di Salerno, 2021-04-29)Base di partenza scientifica e razionale: Il carcinoma del colon-retto (CRC) è una neoplasia maligna molto comune, caratterizzata da un’incidenza stimata intorno al 9-10% ed una mortalità del circa 8-9% (700.000 morti/anno). La ... -
Valorization of typical agricultural productions and related biomasses as sources of bioactive compounds
(Universita degli studi di Salerno, 2019-11-05)Main target of this PhD project was to define the metabolome of the main by-products, and in certain cases of the edible parts, of selected agroalimentary productions, that are the flowers of Opuntia ficus indica Mill. ... -
Espressione genica indotta dall'ormone somatotropo nei monociti di bambini sani e con deficit di GH
(Universita degli studi di Salerno, 2020-07-13)Somatotropic hormone (GH) has transcriptional effects on the cells of many organs, directly by activating its receptor (GHR) or indirectly through induction of IGF-1 or other mediators. The presence of GHR in almost all ... -
Role of vitamin D in the modulation of chronic bowel inflammation and in the genesis of bone mass loss in patients with inflammatory bowel diseases
(Universita degli studi di Salerno, 2020-07-09)Background: Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn’s disease (CD). Bone ... -
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ... -
Cognitive and behavioral features in atypical parkinsonian syndromes
(Universita degli studi di Salerno, 2020-08-14)Introduction Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA), corticobasal degeneration (CBD) and dementia with Lewy Bodies (DLB) are included in atypical parkinsonisms (AP) and they typically involve ... -
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ... -
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ... -
Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
(Universita degli studi di Salerno, 2021-06-17)My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ... -
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ... -
Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis
(Universita degli studi di Salerno, 2021-05-07)Introduction: Non-Alcoholic Fatty Liver Disease encompasses a spectrum of diseases ranging from simple steatosis to steatohepatitis (or NASH), up to cirrhosis and hepatocellular carcinoma(HCC). The challenge is to recognize ... -
Functional and metabolic brain correlates in hearing loss and rehabilitation
(Universita degli studi di Salerno, 2021-04-19)The human auditory system serves the role of extracting information from objects in the environment engaging in analyses of the auditory world so that the listener can accomplish the goal of learning and communication. ...