Browsing Scienze farmaceutiche by Title
Now showing items 16-35 of 41
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Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ... -
Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases
(Universita degli studi di Salerno, 2011-02-21)The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ... -
Design, synthesis and biological evaluation of new small molecules with anti-inflammatory activity
(Universita degli studi di Salerno, 2015-03-18)Per lipossigenasi (nota più comunemente con l'abbreviazione di LOX o LO) si intende una famiglia eterogenea di enzimi in grado di perossidare i lipidi e di causare l'ossigenazione di acidi grassi polinsaturi trasformandoli, ... -
Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ... -
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(Universita degli studi di Salerno, 2015-04-24)Heterocyles are an essencial class of molecules, assuming a role in many aspect of our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and bioactive compounds including agrochemical products ... -
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ... -
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ... -
Design, synthesis, biological studies of new mitochondrial modulators improving neurological deficits in experimental models of Huntington's disease
(Universita degli studi di Salerno, 2017-03-22) -
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ... -
Development of analytical methodology for determination of emerging contaminants in enviroment and food
(Universita degli studi di Salerno, 2015-04-24)In recent years, fate, occurrence and potential adverse effect of emerging contaminants (ECs) in the environment have received an increased attention by scientific community. The ECs are a broad category of chemicals, ... -
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
(Universita degli studi di Salerno, 2012-02-23)It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ... -
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ... -
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ... -
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(Universita degli studi di Salerno, 2016-04-13)The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ... -
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ... -
Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models.
(Universita degli studi di Salerno, 2015-03-18)Direct administration of drugs to the lungs has been used for millennia as a major treatment for a number of diseases. Origin of the inhalation therapies can be found 2000 B.C in India, where people were used to smoke ... -
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(Universita degli studi di Salerno, 2011-10-06)Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple eliche in regioni ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ...