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Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)
One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...