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Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)
The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ...
Study of the mechanism of action of bioactive plants tarpenoids
(Universita degli studi di Salerno, 2016-05-06)
Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ...
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(Universita degli studi di Salerno, 2016-04-20)
The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ...
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(Universita degli studi di Salerno, 2016-04-13)
The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ...
Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)
A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ...
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)
Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ...
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)
The design of new metal complexes as anticancer agents has received considerable interest in
recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.:
texaphyrrins lanthanide) and ...