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Chemical proteomics on ligand protein
(Universita degli studi di Salerno, 2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...