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Items 1231-1250 di 6056
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Desenmascaramiento, inmigración y neo-grotesco criollo: una aproximación a anclado en Madrid de Roberto Ibáñez
(2018)This paper is an analysis of Anclado en Madrid (1991), written by the Argentinean playwright and actor Roberto Ibanez. It focuses on how elements from the “grotesco criollo” tradition from the beginning of the XX Century ... -
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(Universita degli studi di Salerno, 2012-03-07)The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ... -
Design and development of new polymeric materials with potential antimicrobial and/or antifungal activity
(Universita degli studi di Salerno, 2014-12-15)This PhD project is focused on the development of new polymeric materials with antibacterial and antifungal activity. The first part of the work was dedicated to the synthesis and the insertion of a modified amino acid ... -
Design and fabrication of advanced Materials obtained from hemp Fibers and sustainable polymers
(Universita degli studi di Salerno, 2022-07-26)Nowadays, in the frame of sustainability and circular economy, scientific community is focusing on eco- friendly novel materials as valuable alternative of petroleum-based ones. Since the urge of investigating the fabrication ... -
Design and optimization of a protection device for laser weld beads of metal alloys for aerospace applications
(Universita degli studi di Salerno, 2013-09-09)In the present thesis an automated laser welding apparatus was designed and developed in order to perform laser , that allows to achieve laser welding in a controlled, versatile, efficient, reliable, simple, and economical ... -
Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare. Paramount is the necessity of re-organizing the healthcare services ... -
Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents.
(Universita degli studi di Salerno, 2015-03-10)L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ... -
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ... -
Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ... -
Design and synthesis of new integrase inhibitors
(Universita degli studi di Salerno, 2017-03-28)The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ... -
Design and synthesis of new polycyclic compounds with potential anticancer activity
(Universita degli studi di Salerno, 2011-02-21)p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ... -
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters. The title of the thesis clearly reflects the ... -
Design and synthesis of peptides involved in the inhibition of influenza virus infection
(Universita degli studi di Salerno, 2017-03-28)The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ... -
Design and synthesis of peptides that modulate apoptotic process.
(Universita degli studi di Salerno, 2014-11-17)Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ... -
Design and synthesis of “small molecules” as antiviral and radiotracer agents
(Universita degli studi di Salerno, 2011-03-28)The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ... -
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(Universita degli studi di Salerno, 2011-03-07)Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari ... -
Design of a non-invasive system for a real-time monitoring of driver's drowsiness and fatigue through the analysis of cardiac signals
(Universita degli studi di Salerno, 2021-11-02)The development and spread of human-centered products that are increasingly simple and affordable has seen their application areas increase over the years, as well as their effectiveness and reliability. Real-time monitoring ... -
Design of a rapid heating/cooling system: control the properties of micro-injection molded parts
(Universita degli studi di Salerno, 2020-06-19)Microinjection molding (μIM) is one of the most efficient processes for wide scale production of thermoplastic polymer microparts. In order to produce high-quality microinjection-molded components, a crucial aspect to be ... -
Design of monoaxial and coaxial Electrospun membranes for Biomedical applications
(Universita degli studi di Salerno, 2023-02-21)According to the Institute for Health Metrics and Evaluation, cancer is a disease that each year causes above 17% of all global deaths (2017). Currently, the most used therapies are generally administrated orally or ... -
Design, development and on-field testing of advanced solutions for monitoring, diagnosis and fault mitigation of SOFCs
(Universita degli studi di Salerno, 2020-12-20)The work presented in this thesis is aimed at developing an advanced algorithm to monitor the State of Health (SoH) of Solid Oxide Fuel Cells (SOFCs). Then a computational structure has been implemented for the diagnosis ...