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Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)
The inhalation therapy consists of a direct administration of drugs for the treatment of lung
diseases. A formulation for inhalation is a valid option in the symptomatic management of
pulmonary diseases typical of cystic ...
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)
Antimicrobial peptides (AMP) are evolutionarily conserved components of the
innate immune system. They have a broad spectrum of action against bacteria,
fungi and viruses. Therefore, AMP are studied as probable substitutes ...
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...