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Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)
Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ...
Valorization of typical agricultural productions and related biomasses as sources of bioactive compounds
(Universita degli studi di Salerno, 2019-11-05)
Main target of this PhD project was to define the metabolome of the main by-products, and in certain
cases of the edible parts, of selected agroalimentary productions, that are the flowers of Opuntia ficus
indica Mill. ...
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)
The identification of natural products (NPs) target proteins is pivotal to understand their
mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years,
affinity chromatogra ...
Proteomic investigation of the impact of Cannabidiolic acid on Eukaryotic Translation complex in glioblastoma
(Universita degli studi di Salerno, 2023-04-12)
Phytocannabinoids, the major secondary metabolites of cannabis plants, exert a wide range
of biological activities. The present work was focused on investigating the mechanism of
action of cannabidiolic acid (CBDA) in ...
Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)
The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare.
Paramount is the necessity of re-organizing the healthcare services ...
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(Universita degli studi di Salerno, 2022-04-27)
There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to
characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ...
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)
This research aimed to chemical-biological study of plant and fungal species from inland areas of
Campania Region, typically used in preparations for medicinal purposes or food traditional recipes.
In the preliminary ...
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)
Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role
in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant
activity in proteins involved in this ...
Molecular mechanisms of TFF1-Helicobacter cross-talk
(Universita degli studi di Salerno, 2023-04-18)
Helicobacter pylori is one of the most important pathogenic bacteria associated with
various gastric diseases, including cancer. This pathogen induces an acute mucosal
inflammatory response and, if not eradicated, it ...