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An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
(2012)
In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ...
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)
Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ...
Designing in-vitro systems to simulate the in-vivo permeability of drugs
(2014)
In this work an engineering approach,
consisting in an experimental procedure and a model to
derive the data, was presented and applied to improve the
testing methods of pharmaceuticals. The permeability of
several ...