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Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)
Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ...
Development of a versatile screening platform for the identification of small-molecule ligands for reader proteins of the post-translational methylation
(Universita degli studi di Salerno, 2021-06-25)
Covalent Post Translational Modifications (PTMs) of histone proteins are introduced and removed by the
‘writer’ and ‘eraser’ enzymes, respectively. These modifications are recognized by highly specific binding
domains, ...
Clinical characterization, genetic screening and genotype-phenotype associations in cerebellar and brainstem congenital defects
(Universita degli studi di Salerno, 2020-10-01)
Cerebellar and brainstem congenital defects (CBCDs) represent a wide spectrum of malformative
disorders resulting from abnormal development of midbrain-hindbrain and characterised by high
clinical and genetic heterogeneity. ...
Effects of the isoprenoid derivative N6-benzyladenosine in cancer progression
(Universita degli studi di Salerno, 2021-05-07)
N6-isopentenyladenosine (IPA) and its analogue N6-benzyladenosine (N6-BA) are modified nucleosides endowed with potent in vitro antitumor activity on different types of human cancers, including colorectal cancer (CRC) and ...
Cognitive and behavioral features in atypical parkinsonian syndromes
(Universita degli studi di Salerno, 2020-08-14)
Introduction Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA), corticobasal degeneration (CBD) and dementia with Lewy Bodies (DLB) are included in atypical parkinsonisms (AP) and they typically involve ...
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)
Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ...
Development of a bioengineered three-dimensional scaffold able to commit stem cells toward tenogenic phenotype
(Universita degli studi di Salerno, 2021-06-23)
The term tendinopathy is a generic descriptor of tendon disorders. Spontaneous adult
tendon healing results in scar tissue formation and fibrosis, with impaired biological
and mechanical properties. Adult tendons have ...
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)
The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ...
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)
Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ...
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)
Biofluids are typical complex matrices representing a source of potential biomarkers,
but often require high demands in sample preparation prior to analysis. With this purpose,
several techniques have been developed ...