Cerca
Items 1-10 di 10
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)
The inhalation therapy consists of a direct administration of drugs for the treatment of lung
diseases. A formulation for inhalation is a valid option in the symptomatic management of
pulmonary diseases typical of cystic ...
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)
Antimicrobial peptides (AMP) are evolutionarily conserved components of the
innate immune system. They have a broad spectrum of action against bacteria,
fungi and viruses. Therefore, AMP are studied as probable substitutes ...
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
Unraveling biomarkers in Parkinson’s disease: the role of Insulin-like growth factor-1 (IGF-1) and DAT imaging
(Universita degli studi di Salerno, 2018-02-28)
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's
disease, affecting up to 10 million individuals worldwide. Although symptomatic treatment
ameliorates motor symptoms, currently ...
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)
This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ...
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)
My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ...
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)
The adenosinergic pathway plays a critical role in cancer development and progression, as well as
in drug resistance to chemotherapy and/or targeted-therapy.
The goal of this PhD thesis was to investigate and fully ...
Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)
The research project "Chemical and biological study of natural substances active on
the Central Nervous System" has been focused on the possible effects of essential oils,
their main constituents (in particular monoterpenes), ...