1. Elea
  2. Dipartimenti e Centri di ricerca UniSA. Pubblicazioni scientifiche
  3. Translational Medicine @ UniSa
  4. Translational Medicine @ UniSa. Volume 10 (sept.-dec. 2014)
Utilizza questo identificativo per citare o creare un link a questo documento: http://elea.unisa.it/xmlui/handle/10556/1636
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Campo DCValoreLingua
dcterms.contributor.authorCascone, Sara-
dcterms.contributor.authorLamberti, Gaetano-
dcterms.contributor.authorTitomanlio, Giuseppe-
dc.date.accessioned2015-01-29T11:34:13Z-
dc.date.available2015-01-29T11:34:13Z-
dcterms.date.issued2014-
dcterms.identifier.citationCascone S, Lamberti G, Titomanlio G. Designing in-vitro systems to simulate the in-vivo permeability of drugs. Translational Medicine @ UniSa 2014;10(5):14-21-
dcterms.identifier.issn2239-9747en_US
dcterms.identifier.urihttp://hdl.handle.net/10556/1636-
dcterms.identifier.urihttp://dx.doi.org/10.14273/unisa-440-
dc.description.abstractIn this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurementsen_US
dcterms.format.extentP. 14-21en_US
dc.language.isoenen_US
dcterms.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dcterms.subjectPermeabilityen_US
dcterms.subjectArtificial membranesen_US
dcterms.subjectFranz cellen_US
dcterms.subjectIn-vitro/in-vivo correlationsen_US
dcterms.subjectStokes radiusen_US
dcterms.subjectOral deliveryen_US
dcterms.titleDesigning in-vitro systems to simulate the in-vivo permeability of drugsen_US
dcterms.typeArticleen_US
È visualizzato nelle collezioni:Translational Medicine @ UniSa. Volume 10 (sept.-dec. 2014)

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