Please use this identifier to cite or link to this item: http://elea.unisa.it/xmlui/handle/10556/1636

Abstract:

In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurements

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Translational Medicine @ UniSa. Volume 10 (sept.-dec. 2014)

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