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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products 

De Simone, Rosa (2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
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Synthesis and properties of linear and cyclic peptoids 

De Cola, Chiara (2012-03-26)
Le strutture e le attività metaboliche di tutte le cellule si basano su una vasta gamma di molecole comprendenti: amminoacidi, carboidrati, lipidi e nucleotidi, insieme alle forme polimeriche di questi composti. Ognuna di ...
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Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs 

Cafaro, Emiddio (2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari è ...
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Chemical proteomics on ligand protein 

Margarucci, Luigi (2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
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Enzymatic synthesis of macrolactones 

Fortunati, Tancredi (2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a macrolactone structure have been isolated from many natural sources such as plants, insects, marine organism and bacteria. ...
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Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts 

De Fusco, Claudia (2013-01-30)
This PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates ...
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New techniques of molecular modelling and structural chemistry for the development of bioactive compounds 

Lauro, Gianluigi (2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
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Congegni Supramolecolari basati sul Threading di Calixareni 

Talotta, Carmen (2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes exploiting the inducing effect of a weakly coordinating anion, tetrakis ...
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Synthesis, Structure and Properties of Cyclopeptoids and Cyclopeptides 

Nardone, Brunello (2014-01-29)
Aim of the research project has been the synthesis of cyclopeptides and cyclopeptoids in order to investigate their structural properties and catalytic activities. In particular, studies of the arrangement and the cyclopeptoids ...
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New chemical topologies based on calixarene threading 

Ciao, Roberta (2014-03-11)
Recently, Neri et al. have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes by exploiting the inducing effect of the weakly coordinating tetrakis[3, ...
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AutoreAraszczuk, Alicja (1)Cafaro, Emiddio (1)Cantone, Vincenza (1)Capacchione, Clotilde (1)Capaccio, Vito (1)Cassiano, Chiara (1)Ceccacci, Sara (1)Chini, Maria Giovanna (1)Ciao, Roberta (1)Ciarfaglia, Nicola (1)... View MoreSoggetto
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Mass spectrometry (4)Calixareni (2)Cancer (2)Drug discovery (2)mPGES-1 (2)Organocatalysis (2)Proteomics (2)Small molecules (2)Anticancer (1)... View MoreDate Issued2020 - 2023 (21)2011 - 2019 (29)Has File(s)Yes (50)
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