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dc.contributor.authorPalladino, Carmela
dc.contributor.authorBruno, Benedetto
dc.contributor.authorBoccadoro, Mario
dc.date.accessioned2014-06-04T09:59:16Z
dc.date.available2014-06-04T09:59:16Z
dc.date.issued2014
dc.identifier.citationPalladino C, Bruno B, and Boccadoro M. Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges. Translational Medicine @ UniSa 2014;8(3):12-18en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/1379
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-228
dc.description.abstractMonoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular neoplasms, Waldenstrom Macroglobulinemia or light chain amyloidosis). It is a quite common finding, especially in the population above the age of 50 and it can also present in association with many non malignant conditions. Differential diagnosis of symptomatic and asymptomatic forms is the determinant for starting therapy. Over the last few years many advances in the understanding of the biology of MGUS, together with large epidemiological studies, allowed to define risk models to estimate the risk of progression to MM according to MGUS isotype and, more recently, to peculiar flow cytometry findings. The goal of many recent studies aims at evaluating individual patients and their overall risk of progression, the detection of early signs of progression and the development of timely treatment strategies.en_US
dc.format.extentP. 12-18en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectMGUSen_US
dc.subjectMonoclonal gammopathy of undetrmined significanceen_US
dc.subjectNon malignant haematological disordersen_US
dc.subjectPre-malignant haematological neoplasmsen_US
dc.titleDiscovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challengesen_US
dc.typeArticleen_US
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