Sfoglia Translational Medicine @ UniSa. Volume 13 (sept.-dec. 2015) per Soggetto "Aging"

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    • Models for preclinical studies in aging-related disorders: one is not for all 

      Santulli, Gaetano; Borras, Consuelo; Bousquet, Jean; Calzà, Laura; Cano, Antonio; Illario, Maddalena; Franceschi, Claudio; Liotta, Giuseppe; Maggio, Marcello; Molloy, William D.; Montuori, Nunzia; O’Caoimh, Rónán; Orfila, Francesco; Rauter, Amelia P.; Santoro, Aurelia; Iaccarino, Guido (2015)
      Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. ...

    • Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation 

      Marzetti, E.; Calvani, R.; Cesari, M.; Tosato, M.; Cherubini, A.; Di Bari, M.; Pahor, M.; Savera, G.; Collamati, A.; D'Angelo, E.; Bernabei, R.; Landi, F. (2015)
      Over the years, different operational definitions have been elaborated to identify frail older persons, but none of them has received unanimous consensus. This, in turn, has hampered the clinical implementation of frailty ...