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dcterms.contributor.authorCimmino, Giovanni
dcterms.contributor.authorCiccarelli, Giovanni
dcterms.contributor.authorMorello, Alberto
dcterms.contributor.authorCicarelli, Michele
dcterms.contributor.authorGolino, Paolo
dc.date.accessioned2016-06-17T12:27:50Z
dc.date.available2016-06-17T12:27:50Z
dcterms.date.issued2015
dcterms.identifier.citationCimmino G, Ciccarelli G, Morello A, Cicarelli M, Golino P. High density lipoprotein cholesterol increasing therapy: the unmet cardiovascular need. Translational Medicine @ UniSa 2015, 12(6): 29-40it_IT
dcterms.identifier.issn2239-9747it_IT
dcterms.identifier.urihttp://hdl.handle.net/10556/2104
dc.description.abstractDespite aggressive strategies are now available to reduce LDL-cholesterol, the risk of cardiovascular events in patients with coronary artery disease remains substantial. Several preclinical and clinical studies have shown that drug therapy ultimately leads to a regression of the angiographic lesions but also results in a reduction in cardiovascular events. The dramatic failure of clinical trials evaluating the cholesterol ester transfer protein (CEPT) inhibitors, torcetrapib and dalcetrapib, has led to considerable doubt about the value of the current strategy to raise high-density lipoprotein cholesterol (HDL-C) as a treatment for cardiovascular disease. These clinical results, as well as animal studies, have revealed the complexity of HDL metabolism, assessing a more important role of functional quality compared to circulating quantity of HDL. As a result, HDL-based therapeutic interventions that maintain or enhance HDL functionality, such as improving its main property, the reverse cholesterol transport, require closer investigation. In this review, we will discuss HDL metabolism and function, clinical-trial data available for HDL-raising agents, and potential strategies for future HDL-based therapies.it_IT
dcterms.format.extentP. 29-40it_IT
dc.language.isoenit_IT
dcterms.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dcterms.subjectAtherosclerosisit_IT
dcterms.subjectReverse cholesterol transportit_IT
dcterms.subjectCholesterol Effluxit_IT
dcterms.subjectApolipoprotein AIit_IT
dcterms.subjectHDLit_IT
dcterms.titleHigh density lipoprotein cholesterol increasing therapy: the unmet cardiovascular needit_IT
dcterms.typeJournal Articleit_IT
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