Mostra i principali dati dell'item

dc.contributor.authorSantulli, Gaetano
dc.contributor.authorBorras, Consuelo
dc.contributor.authorBousquet, Jean
dc.contributor.authorCalzà, Laura
dc.contributor.authorCano, Antonio
dc.contributor.authorIllario, Maddalena
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorLiotta, Giuseppe
dc.contributor.authorMaggio, Marcello
dc.contributor.authorMolloy, William D.
dc.contributor.authorMontuori, Nunzia
dc.contributor.authorO’Caoimh, Rónán
dc.contributor.authorOrfila, Francesco
dc.contributor.authorRauter, Amelia P.
dc.contributor.authorSantoro, Aurelia
dc.contributor.authorIaccarino, Guido
dc.date.accessioned2016-07-27T10:15:37Z
dc.date.available2016-07-27T10:15:37Z
dc.date.issued2015
dc.identifier.citationSantulli G, Borras C, Bousquet J, Calzà L, Cano A, Ilario M, Franceschi C, Liotta G, Maggio M, Molloy W. D, Montuori N, O’Caoimh R, Orfila F, Rauter A. P, Santoro A, Iccarino G. Models for preclinical studies in aging-related disorders: one is not for all. Translational Medicine @ UniSa 2015, 13(2): 4-12it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://hdl.handle.net/10556/2160
dc.description.abstractPreclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. Researchers aim to demonstrate a causal relationship between an investigational agent and a disease-related phenotype in such models. Numerous factors can muddle reliable inferences about such causeeffect relationships, including biased outcome assessment due to experimenter expectations. For instance, responses in a particular inbred mouse might be specific to the strain, limiting generalizability. Selecting well-justified and widely acknowledged model systems represents the best start in designing preclinical studies, especially to overcome any potential bias related to the model itself. This is particularly true in the research that focuses on aging, which carries unique challenges, mainly attributable to the fact that our already long lifespan makes designing experiments that use people as subjectsextremely difficult and largely impractical.it_IT
dc.format.extentP. 4-12it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectAgingit_IT
dc.subjectAnimal modelsit_IT
dc.subjectRodentsit_IT
dc.subjectSwineit_IT
dc.subjectCardiovascular medicineit_IT
dc.subjectPreclinical studiesit_IT
dc.subjectFrailtyit_IT
dc.subjectMultimorbidityit_IT
dc.titleModels for preclinical studies in aging-related disorders: one is not for allit_IT
dc.typeJournal Articleit_IT
 Find Full text

Files in questo item

Thumbnail

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item