Browsing Dipartimenti e Centri di ricerca UniSA. Pubblicazioni scientifiche by Author "Lamberti, Gaetano"
Now showing items 1-4 of 4
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Designing in-vitro systems to simulate the in-vivo permeability of drugs
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe (2014)In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several ... -
An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe (2012)In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ... -
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
Cascone, Sara; Lamberti, Gaetano; Titomanlio, Giuseppe; Piazza, Ornella (2013)Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ... -
SiRNA delivery for control of cyclin d1 and e2f1 expression in crohn’s disease
Russo, Ilaria; Carrizzo, Albino; Bochicchio, Sabrina; Piazza, Ornella; Lamberti, Gaetano; Barba, Anna Angela; Vecchione, Carmine; Zeppa, Pio; Iovino, Paola; Bucci, Cristina; Santonicola, Antonella; Ciacci, Carolina (2017)Evidence in inflammatory bowel diseases (IBD) supports a connection between inflammation and cancer due to the alteration of the cell cycle with loss of control at the G1/S checkpoint. In this study, we analyze ...