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dc.contributor.authorRossi, Francesca Wanda
dc.contributor.authorPrevete, Nella
dc.contributor.authorRivellese, Felice
dc.contributor.authorNapolitano, Filomena
dc.contributor.authorMontuori, Nunzia
dc.contributor.authorPostiglione, Loredana
dc.contributor.authorSelleri, Carmine
dc.contributor.authorDe Paulis, Amato
dc.date.accessioned2020-05-22T12:41:55Z
dc.date.available2020-05-22T12:41:55Z
dc.date.issued2016
dc.identifier.citationRossi FW, Prevete N, Rivellese F, Napolitano F, Montuori N, Postiglione L, Selleri C, de Paulis A. The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors. Translational Medicine @ UniSa 2016, 15(5): 34-41.it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://www.translationalmedicine.unisa.it/indexit_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/4479
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2677
dc.description.abstractMast cell and basophils express the high affinity receptor for IgE (FcRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological and pathological events based on cell migration and tissue remodelling, such as inflammation, wound healing, angiogenesis and metastasis. uPA is a serine protease that binds uPAR, a high affinity glycosyl-phosphatidyl-inositol (GPI)- anchored receptor. uPAR focuses uPA activity at the cell surface and activates intracellular signaling through lateral interactions with integrins, receptor tyrosine kinases and the G-protein-coupled family of fMLF chemotaxis receptors (FPRs). We investigated the expression of the uPAuPAR system and its functional interaction with FPRs in human mast cells (MCs). Differently from basophils, MCs produced uPA that was able to induce their chemotaxis. Indeed, MCs also expressed uPAR, both in the intact and in a cleaved form (DIIDIII-uPAR) that can expose, at the N-terminus, the SRSRY sequence, able to interact with FPRs and to mediate cell chemotaxis. MCs also expressed mRNAs for FPRs that were functionally active; indeed, uPA and a soluble peptide (uPAR84-95), containing the SRSRY chemotactic sequence of uPAR and able to interact with FPRs, were able to induce MCs chemotaxis. Thus, uPA is a potent chemoattractant for MCs acting through the exposure of the chemotactic epitope of uPAR, that is an endogenous ligand for FPRs. The same mechanism could be involved in VEGF-A secretion by human MCs, also induced by uPA and uPAR84-95 stimulation.it_IT
dc.format.extentP. 34-41it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectMast Cellsit_IT
dc.subjectFPRsit_IT
dc.subjectuPA/uPARit_IT
dc.subjectVEGF-Ait_IT
dc.titleThe urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptorsit_IT
dc.typeArticleit_IT
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