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dc.contributor.authorPiazza, Ornella
dc.contributor.authorRomano, Rosalba
dc.contributor.authorScarpati, Giuliana
dc.contributor.authorEsposito, Ciro
dc.contributor.authorCavaglià, Enrico
dc.contributor.authorCorona, Marco
dc.date.accessioned2013-05-29T09:01:51Z
dc.date.available2013-05-29T09:01:51Z
dc.date.issued2012
dc.identifier.citationPiazza O, Romano R, Scarpati G, Esposito C, Cavaglià E, Corona M. Minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs. Translational Medicine @ UniSa 2012;4(7):62-65en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/637
dc.description.abstractPurpose: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. Materials and Methods: review of literature and elaboration of a hypothesis, design of an experimental method. Results: recent clinical studies were conducted by withdrawing cirrhotic patients’ blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed. Conclusions: contemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivoen_US
dc.format.extentP. 62-65en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectLiveren_US
dc.subjectHepatic veinsen_US
dc.subjectRemifentanil metabolismen_US
dc.titleMinimally invasive swine experimental model for the in vivo study of liver metabolism of drugsen_US
dc.typeArticleen_US
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