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Studio delle relazioni tra alimentazione e stati fisiopatologici mediante un approccio di biologia dei sistemi
(Universita degli studi di Salerno, 2016-09-30)
Lifestyle and food choices have an important role in the onset and in the prevention of
some diseases. The assumption of some food-related molecules can have different
effects on human health; for example, the antioxidants ...
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(Universita degli studi di Salerno, 2016-05-10)
My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(Universita degli studi di Salerno, 2015-04-22)
Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it
may be a consequence of a reduced availability of this hormone, of an impediment to its normal
action, or of a combination ...
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma
(Universita degli studi di Salerno, 2016-05-24)
Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant
neoplasia. Oncogene activation occurs in more than 70% of the cases. BRAF
mutations occur in about 40% of PTCs, whereas RET rearrangements ...
Studio del ruolo della proteina anti-apoptotica BAG3 nel melanoma umano
(Universita degli studi di Salerno, 2016-07-07)
BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating ...
Regolazione post-trascrizionale dell’espressione del recettore dell’urochinasi
(Universita degli studi di Salerno, 2016-12-14)
The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored
cell surface receptor. uPAR expression is strongly up-regulated and represents a
negative prognostic factor in various tumors, including ...
Compression and indexing of genomic data with confidentiality protection
(Universita degli studi di Salerno, 2015-04-30)
The problem of data compression having specific security properties in order to guarantee
user’s privacy is a living matter. On the other hand, high-throughput systems in genomics
(e.g. the so-called Next Generation ...
Regolazione epigenetica dell’espressione del fattore peptidico gastrointestinale TFF1
(Universita degli studi di Salerno, 2016-04-19)
TFF1 is a protein expressed in the gastrointestinal tract, belonging to the trefoil folding factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a cloverleaf disulfide ...
Studio del meccanismo d’azione e dei parametri strutturali di nuovi materiali ad azione antimicrobica
(Universita degli studi di Salerno, 2017-03-28)
The increased demand of new and more effective materials able to reduce and prevent microbiological contamination is one of the great challenges of scientific research. In the last decade, the use of antimicrobial polymers ...
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)
Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ...