Area Scienze mediche
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Role of H3K56 acetylation in Candida albicans virulence
(Universita degli studi di Salerno, 2022-12-20)Candida spp., especially Candida albicans, represent the third most frequent cause of infection in Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal resistance drastically ... -
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(Universita degli studi di Salerno, 2022-05-03)La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ... -
Development of Innovative Agents for the Treatment of Metabolic Diseases
(Universita degli studi di Salerno, 2022-05-10)Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ... -
High-throughput virtual screening by molecular dynamics assisted molecular docking.
(Universita degli studi di Salerno, 2022-04-29)Molecular docking is a widely used Structure-Based method for drug discovery. Over the years, molecular docking methodologies have evolved to address several limitations, such as high errors in predicting pose and binding ... -
Design and synthesis of small molecules as ion channel modulators
(Universita degli studi di Salerno, 2022-05-02)My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of ... -
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(Universita degli studi di Salerno, 2022-04-26)Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile che include il peptide di ... -
“profilo microbiomico e metabolomico in soggetti con anoressia nervosa prima e dopo recupero di peso: un approccio multi-omico”
(Universita degli studi di Salerno, 2022-05-31)Sebbene l'eziopatogenesi dell'Anoressia Nervosa (AN) non sia ancora del tutto nota, tra i possibili meccanismi patogenetici sono state proposte le alterazioni dei sistemi di regolazione dell'alimentazione. Recentemente, ... -
Development and application of omics technologies for the monitoring of personalized therapeutic protocols
(Universita degli studi di Salerno, 2022-05-05)During the 1st year the scientific activity was focused on the development of an experimental protocol aimed to evaluate the possible involvement of Sortilin (Sort), a membrane glycoprotein, in the modulation of sphingolipids ... -
La Sicurezza in Ospedale: dalla tradizione all’innovazione. Elaborazione di un piano di intervento multimodale per la riduzione del rischio infezioni nosocomiali
(Universita degli studi di Salerno, 2022-03-16)La sanità in Italia occupa più del 7% del Prodotto Interno Lordo nazionale (PIL) ed in media rappresenta circa l’80% dei bilanci regionali. Questi due semplici dati, in un contesto di evidente progressione dell’invecchiamento ... -
Annexin A1 in pancreatic cancer progression
(Universita degli studi di Salerno, 2022-02-02)Pancreatic cancer (PC) is one of the most aggressive cancers in the world and it correlates to poor prognosis and high mortality due to late diagnosis, even if early diagnosed. Resectable PC patients have unfavorable outcome ... -
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(Universita degli studi di Salerno, 2023-04-13)My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary ... -
Molecular mechanisms of TFF1-Helicobacter cross-talk
(Universita degli studi di Salerno, 2023-04-18)Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it ... -
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this ... -
Targeted and untargeted proteomic approaches to disclose small molecules interactome
(Universita degli studi di Salerno, 2023-04-24)The identification of natural products and synthetic compounds target proteins is pivotal to understand their mechanism of action for the development of molecular probes and/or potential drugs. Functional proteomics is ... -
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(Universita degli studi di Salerno, 2022-10-20)Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D printing ... -
Role of CD73 in patients with advanced melanoma treated with anti-PD-1 agents
(Universita degli studi di Salerno, 2022-04-04)The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD- 1), such as nivolumab and pembrolizumab. ... -
Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(Universita degli studi di Salerno, 2022-05-02)The aim of this Ph.D. project is the development of novel topical formulations for the treatment of various wounds by innovative technologies (micro and nano spray drying). The specific objective is the production of a ...
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