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Molecular dynamics investigations of drug-cell membrane interactions
(Universita degli studi di Salerno, 2013-04-22)
The cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks.
The complex dynamic structure of the plasma membrane ...
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(Universita degli studi di Salerno, 2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)
The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ...
A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
(Universita degli studi di Salerno, 2013-10-14)
Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts
(Universita degli studi di Salerno, 2013-01-30)
This PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates ...
Improving the aircraft safety by advanced structures and protecting nanofillers
(Universita degli studi di Salerno, 2014-04-24)
Inspection and Maintenance are important aspects when considering the availability of aircraft for revenue flights. Modern airframe design is exploiting new exciting developments in materials and structures to construct ...
Congegni Supramolecolari basati sul Threading di Calixareni
(Universita degli studi di Salerno, 2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity
complexation and through-the-annulus threading of large calixarenes exploiting the
inducing effect of a weakly coordinating anion, tetrakis ...
Innovative processes for the production of new nanocomposite materials by electrospinning technique
(Universita degli studi di Salerno, 2013-03-19)
The technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has ...
Supercritical assisted processes for the production of biopolymeric micro and nanocarriers
(Universita degli studi di Salerno, 2015-04-20)
This work provides an innovative point of view on obtaining nanoparticles by supercritical fluids. Supercritical fluids have already been exploited in the production and processing of micro or sub-micro particles, but the ...
Forest fire modelling
(Universita degli studi di Salerno, 2015-04-21)
Wildland fires have always been undesired and dangerous events. The danger includes the destruction of a renewable natural resource, damage of the atmospheric environment through the emissions of pollutant gases, which ...