p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...

Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ...

There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ...

My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of our ...

A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ...

Per lipossigenasi (nota più comunemente con l'abbreviazione di LOX o LO) si intende una famiglia eterogenea di enzimi in grado di perossidare i lipidi e di causare l'ossigenazione di acidi grassi polinsaturi trasformandoli, ...

My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ...

Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive extracts ...

The design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and ...