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Now showing items 31-36 of 36
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(2022-04-26)
Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono
la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile
che include il peptide di ...
Development of Innovative Agents for the Treatment of Metabolic Diseases
(2022-05-10)
Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the
leading cause of death in the world. To date three main therapeutic strategies have been evaluated to
reduce circulating LDL-C ...
Development and application of omics technologies for the monitoring of personalized therapeutic protocols
(2022-05-05)
During the 1st year the scientific activity was focused on the development of an experimental protocol
aimed to evaluate the possible involvement of Sortilin (Sort), a membrane glycoprotein, in the
modulation of sphingolipids ...
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(2023-04-13)
My PhD research plan relates to the exploration of the structural requirements for the modulation
of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part
of my doctoral project ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...
Effects of natural iron chelators on dendritic cells: anti-inflammatory activity, phenotypic characterization, and metabolomic analysis
(2022-12-16)
Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the
body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate
the adaptive ...