Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...

Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ...

The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ...

The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ...

Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate the adaptive ...

Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ...

La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ...

Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile che include il peptide di ...

My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of ...

During the 1st year the scientific activity was focused on the development of an experimental protocol aimed to evaluate the possible involvement of Sortilin (Sort), a membrane glycoprotein, in the modulation of sphingolipids ...