Browsing Chimica by Title
Now showing items 1-20 of 93
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A computational approach to investigate the interactions between potential pharmacological chaperones and GALT enzyme
(Universita degli studi di Salerno, 2023-03-13)Classic galactosemia is an inborn error of metabolism associated with mutations that impair the activity and the stability of the dimeric enzyme galactose-1-phosphate uridylyltransferase (GALT), which catalyzes the third ... -
An ecological approach to the integrated monitoring of freshwater ecosystems
(Universita degli studi di Salerno, 2019-02-06)The concept of integrated environmental monitoring includes the gathering of all the information necessary to obtain a comprehensive view of ecosystem status, processes and functionality, through a classical ecological ... -
Analysis of biochemical pathways involved into protective effects of bioactive compounds: focus on Omega-3 Polyunsaturated Fatty Acids
(Universita degli studi di Salerno, 2022-06-06)Dietary fat sources differently affect cellular metabolism, with different effects on metabolic disease risks. In the present PhD thesis, it was evaluated the effect of Omega-3 Polyunsaturated Fatty Acids (Omega-3 PUFAs), ... -
Asymmetric synthesis of Heterocyclic Compounds through cascade Carbon-Carbon and Carbon-Heteroatom bond forming processes
(Universita degli studi di Salerno, 2023-06-06)The aim of my PhD thesis was focused on the asymmetric synthesis of new heterocyclic compounds using cascade and tandem processes involving the formation of new binding Carbon-Carbon and Carbon- Heteroatom. Heterocyclic ... -
Biodegradable and functional aliphatic co-polyesters
(Universita degli studi di Salerno, 2016-03-15)Over the past decades, aliphatic polyesters have found rapidly increasing interest. Linear aliphatic polyesters, such as poly(glycolide) (PGA), poly(lactide) (PLA), poly(ε−caprolactone) (PCL) and their copolymers have found ... -
Bioinspired supramolecular catalysis in nanoconfined space
(Universita degli studi di Salerno, 2021-04-17)The nanoconfinement in Nature is the key for the selectivity of enzymatic reactions: when the substrates are confined in the enzyme pocket, overconcentration and proximity effects promote the reaction in very efficient and ... -
Calixarene based catalytic systems
(Universita degli studi di Salerno, 2018-02-22)Catalysis is the essence of chemistry as it provides useful tools to make and brake chemical bonds. As nature has been a guide to many scientists, it’s no surprise that in the field of catalysis enzymes were a source of ... -
Capsicum annuum L.cv senise and solanum aethiopicum L.cv Rotonda: phytochemical profile and cell-based assays
(Universita degli studi di Salerno, 2021-05-10)Natural products rich in health-promoting compounds could represent new potential therapy strategy in many diseases. In the present study we focus our attention on Capsicum annuum L. cv Senise and Solanum aethiopicum L. ... -
Carbon-based nanomaterials
(Universita degli studi di Salerno, 2017-02-27)New layered carbon-based materials were prepared and exhaustively characterized exploiting different characterization techniques, such as thermogravimetry (TGA), differential thermal calorimetry (DSC), Fourier transform ... -
Catalysis for the transformation of biomass in value-added products
(2019-02-04)The present doctoral thesis is focused on the catalytic conversion of bioglycidol into value-added products... [edited by Author] -
Cavity Filling and Chirality Effects in Calixarene Threading
(Universita degli studi di Salerno, 2016-03-16)In 2010, the Prof. Neri’s group showed that the calix[6]arene hosts were able to recognize dialkylammonium axles when they were coupled with the weakly coordinating Tetrakis[3,5 bis(triFluoromethyl)Phenyl]Borate (TFPB−) ... -
Charge transfer in organic materials with potential applications in electronics
(Universita degli studi di Salerno, 2019-02-05)Search for low cost electronic materials has led towards the synthesis and the employment of organic semiconductors (OSCs), a class of materials that combine the electronic advantages of semiconducting materials with the ... -
Chiral Bioactive Cyclopeptoids: Concepts and Purposes
(Universita degli studi di Salerno, 2020-02-09)Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ... -
Chiral organocatalysts mediated asymmetric oxyfunctionalization and tandem reaction
(Universita degli studi di Salerno, 2015-03-13)Asymmetric organocatalysis is a new rapidly growing field whose huge potential is becoming more and more evident.This PhD project has been conceived and developed in the context of non-covalent organocatalysis. The aim of ... -
CO2 fixation in cyclic carbonates and polycarbonates by salen-like based metal complexes
(Universita degli studi di Salerno, 2019-02-06)At the current rate of consumption of petroleum resources, they are predicted to be exhausted within the next century. For this reason, the development of new chemical processes using biorenewable resources is attracting ... -
Combined adsorption and solar driven photocatalysis processes for the removal of persistent contaminants from water by highly porous nanocomposite aerogels
(Universita degli studi di Salerno, 2021-07-26)Water is a very important resource for human and ecosystem. However, in recent years the presence of pollutants, such as pharmaceuticals, cosmetics, personal cares, dyes, and pesticides deriving from industrial, agricultural, ... -
Comparative studies on the physiological adaption of mitochondria and endoplasmic reticulum to envirnmental xenobiotics from invertebrate to mammals
(Universita degli studi di Salerno, 2021-04-20)Mitochondria are critical for numerous cellular and biochemical processes. The reciprocal interaction between mitochondria and the endoplasmic reticulum impacts several cellular functions. In cellular and animal models, ... -
Complexes of coinage metals stabilized by N-heterocyclic carbenes: catalytic and biological activities
(Universita degli studi di Salerno, 2022-05-30)Since the synthesis, the isolation, and the characterization of the first stable N-heterocyclic carbene (NHC) in 1991 by Arduengo and collaborators, this class of ligands has attracted the attention of researchers for ... -
Copolymerization of olefins with polar monomers by transition metal catalysts
(Universita degli studi di Salerno, 2022-06-13)The investigation into copolymerizing olefins by Ni(Il) complexes bearing pyridylimine ligands was achieved in this study. The complexes, in the presence of a proper activating agent, were found to generate active catalysts ... -
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(Universita degli studi di Salerno, 2011-03-07)Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari è ...