Sfoglia Scienze del farmaco per Titolo
Items 8-27 di 34
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Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare. Paramount is the necessity of re-organizing the healthcare services and ... -
Design and synthesis of molecules with anti-inflammatory and/or anti-cancer activit
(Universita degli studi di Salerno, 2022)Nell'ultimo decennio, il legame tra infiammazione e cancro è risultato sempre più evidente; di conseguenza, l'identificazione di nuove molecole in grado di interferire con i targets biologici chiave coinvolti in queste ... -
Design and synthesis of small molecules as ion channel modulators
(Universita degli studi di Salerno, 2022-05-02)My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of our ... -
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(Universita degli studi di Salerno, 2023-04-13)My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral project ... -
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(Universita degli studi di Salerno, 2022-04-26)Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile che include il peptide di ... -
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(Universita degli studi di Salerno, 2022-05-03)La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ... -
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(Universita degli studi di Salerno, 2022-04-27)There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ... -
Development of Innovative Agents for the Treatment of Metabolic Diseases
(Universita degli studi di Salerno, 2022-05-10)Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ... -
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this crucial ... -
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)The inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic ... -
Effects of natural iron chelators on dendritic cells: anti-inflammatory activity, phenotypic characterization, and metabolomic analysis
(Universita degli studi di Salerno, 2022-12-16)Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate the adaptive ... -
High-throughput virtual screening by molecular dynamics assisted molecular docking.
(Universita degli studi di Salerno, 2022-04-29)Molecular docking is a widely used Structure-Based method for drug discovery. Over the years, molecular docking methodologies have evolved to address several limitations, such as high errors in predicting pose and binding ... -
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive extracts ... -
Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(Universita degli studi di Salerno, 2022-05-02)The aim of this Ph.D. project is the development of novel topical formulations for the treatment of various wounds by innovative technologies (micro and nano spray drying). The specific objective is the production of a dry ... -
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatography-coupled ... -
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ... -
Molecular mechanisms of TFF1-Helicobacter cross-talk
(Universita degli studi di Salerno, 2023-04-18)Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it could ... -
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...
