My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ...

Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...

The inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic ...

Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ...

Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...

This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ...

Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...

Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ...

During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ...