Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive extracts ...

The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatography-coupled ...

Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it could ...

Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ...

The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD- 1), such as nivolumab and pembrolizumab. ...

Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...

Main target of this PhD project was to define the metabolome of the main by-products, and in certain cases of the edible parts, of selected agroalimentary productions, that are the flowers of Opuntia ficus indica Mill. ...