Browsing Scienze del farmaco by Title

Now showing items 17-22 of 22

    • Role of CD73 - A2A/A2B receptors axis in cancer 

      Sorrentino, Claudia (Universita degli studi di Salerno, 2018-04-05)
      The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ...

    • Role of TFF1 in tumor progression 

      Romano, Elena (Universita degli studi di Salerno, 2017-03-31)
      Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...

    • Structural investigation of gp36-MPER in membrane mimicking systems 

      Stillitano, Ilaria (Universita degli studi di Salerno, 2019-05-07)
      FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ...

    • Target-based study to identify new bioactive diterpenes 

      Fiengo, Lorenzo (Universita degli studi di Salerno, 2019-04-16)
      Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ...

    • Technologies for the development of health products based on up-cycling of agro-food by-products 

      Esposito, Tiziana (Universita degli studi di Salerno, 2019-04-12)
      The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ...

    • The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer 

      Chieppa, Marcello (Universita degli studi di Salerno, 2019-05-07)
      During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ...