L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ...

Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ...

The aim of this PhD project has been to develop new synthetic strategies in enantioselective preparation of natural products. In particular my attention has been focused on preparation of some natural metabolite, containing ...

Plant cells represent a valid source of cosmetic ingredients since their extracts can be considered bio-sustainable, contaminant-free and standardized secondary metabolites mixtures (Barbulova et al., 2014). This PhD project ...

Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this crucial ...

The aim of my PhD thesis was focused on the asymmetric synthesis of new heterocyclic compounds using cascade and tandem processes involving the formation of new binding Carbon-Carbon and Carbon- Heteroatom. Heterocyclic ...

Masked esters/amides are scaffolds endowed with a great potential in the field of organic synthesis. This PhD project has been conceived, in the context of non-covalent organocatalysis, with the aim to exploit unsaturated ...

Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ...

The increasing demand for the stereoselective synthesis of bioactive compounds in both industrial and academic research has led to the rapid development of a variety of diastereo- and enantio-selective processes using phase ...

The identification of natural products and synthetic compounds target proteins is pivotal to understand their mechanism of action for the development of molecular probes and/or potential drugs. Functional proteomics is a ...