To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
Mostra/ Apri
Data
2012Autore
Sorriento, Daniela
Illario, Maddalena
Finelli, Rosa
Iaccarino, Guido
Metadata
Mostra tutti i dati dell'itemAbstract
Nuclear factor B (NFB) is a transcription
factor that plays an important role in carcinogenesis as well
as in the regulation of inflammatory response. NFB is
constitutively expressed in tumours where it induces the
expression of genes which promote cell proliferation,
apoptotic events, angiogenesis, invasion and metastasis.
Furthermore, many cancer cells show aberrant or
constitutive NFB activation that mediates resistance to
chemo- and radio-therapy. Therefore, the inhibition of NFB
activity appears a potential therapeutic strategy for cancer
treatment. In this review, we focus on the role of NFB in
carcinogenesis and summarize actual inhibitors of NFB that
could be potential therapeutic target in cancer therapy.